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Novel Process of Enzymatic Synthesis of 5'-Nucleotides

Introduction

Ribonucleic acid was enzymatically degraded with phosphodiesterase and four kinds of 5'-nucleotides(AMP, GMP, CMP, UMP) was separated and purified to form high quality single nucleotide.

In the process the production of enzyme was so simple that the investment and production cost declined 10-15% and environment pollution reduced. In enzyme catalyze reaction the conversion yield increased 15% more than in old one. Because novel separation process was introduced four kind of single high purified nucleotide could be once obtained through combination of novel ion exchange columns. The whole yied increased to 67% from 50%. The products quality also was improved to above 98% from 90%.

    The novel process was authenticated by Shandong Technology Committee and obtained first award in Shanghai Selective Competition of Excellent Invention in 2001.The separation process was original creation in our country and had been applied to patent.5'-Nucleotides can be use as intermediate of nucleic acid pharmacy, food additive, function food and biochemistry reagents. The products had been exported to Europe and America and good appraise were obtained. Now the products was demanded exceeds supply.