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Enzyme Engineering Laboratory in ECUST R&D Center of Bioqiuzhiyou |
| Direction of Research is Enzyme, Immobilized Enzyme, Biosynthesis of Nucleosides and Nucleotides, Seperation of Biochemical Compounds, Pharmacy of Nucleic acid and Functional Food. |
| Main Rearch£º |
| 1) Study and Application of the Technology of Immobilization and Biosynthesis in company with ATP Reproduction, such as Biosynthesis of Nucleosides(or deoxynucleosides) triphosphate (CTP, ATP, UTP, GTP, dATP, dCTP, dGTP, TTP), Cytidine diphosphate Choline(CDP-C), Sugar-nucleotides et al.£» |
| 2) Enzymatic Synthesis of Pharmaceutical or Intermediates of Anti-viral or Anti-cancer, such as Enzymatic synthesis of 5-methyluridine,5-fluorouridine, Ribavirin, 2'-doexyadenosine, 2'-deoxyguanosine, 2,6-diaminopurine deoxynucleoside, 2,6-diaminopurine nucleoside et al.£» |
| 3) Fermental Production of Nucleic acid and analogus and Regulation of Key enzyme in Fermentation Process, Such as Fermental Production of D-Ribose, Nucleosides, Nucleotides et al. |
| 4) Enzymatic preparation of nucleotides, such as 5'- ribonucleotides(adenosine monophosphate, uridine monophosphate, guanosine monophosphate, cytidine monophosphate), 3'-deoxynucleotides, 5'-deoxynucleotides(adenosine monophosphate, cytidine monophosphate, guanosine monophosphate disodium, uridine monophosphate disodium), 2'-deoxynucleotides(2'-deoxyadenosine monophosphate, 2'-deoxycytidine monophosphate, 2'-deoxyguanosine monophosphate disodium, thymidine monophosphate disodium). |
| 5) Molecular clone of enzymes in the metabolism of nucleic acid. |
| 6) Other research and technical service of nucleic acid analogs, enzyme and microorganism. |
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Advantage of our Laboratory |
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Nucleic
acid and derivates were started to research in our Lab before eighty in 20th
century. Through thirty years of great efforts, we developed lots of new processes,
such as "New process of production of Cytidine diphosphate Choline", "Production
of ATP with Immobilized cells", "Novel process of Enzymatic synthesis of
ribavirin", "Enzymatic synthesis of thymidine,
2'-deoxy-5-fluorouridine,5-methyluridine, 5-fluorouridine,
adenine arabinoside",
"Biosynthesis of CTP with Immobilized cells", "Fermentation of D-Ribose",
"Enzymatic synthesis of 2'-deoxyadenosine and 2'-deoxyguanosine". Five
items of State "Seven-Five","Eight-Five" and "Nine-Five" tackle key problems,
three of Shanghai Economics Committee and one of Shandong Economics
Committee were undertook and completed
in these years. We created novel mechanisms and methods of
biosynthesis of nucleic acid pharmacy with enzmye or immobilized. Project of CDP-C,
ATP, four nucleotides or deoxynucleotides and K-carrageenan developed by our lab had industrializated
and much successful experience was acquired. We obtained 15 patents and 14 had
been applied. 11 harvests had been authenticated or checked and accepted.
We win one
Advancement Third Class Medal of Science & Technology from State Education
Committee, two Golden Medals (Functionary Invention) in Shanghai Select
Competion of Excellence Invention,
one Golden Medal in
Chinese Achievement Exhibition of Ten-Year Patents and one Golden Medal in
Third Chinese Patents Exposition.
We had developed a complete set of plans and techniques about nucleic acid
pharmacy and accumulated much industrialization experience and lesson. Products
and technique developed could be competed internationally and attained
advanced level. |
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Address£ºMail Box 365, East China University of Science & Technology , Shanghai, China. |
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| Post Code: 200237 |
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Link man: Dr. Stones King |
| Phone: 0086-21-64250676 | Fax: 0086-21-64250676 | Mobile phone: 86 13817070495 |